Integrated microfluidic systems for cell culture and characterization

TitleIntegrated microfluidic systems for cell culture and characterization
Publication TypeConference Paper
Year of Publication2008
AuthorsFlueckiger, J., and K. C. Cheung
Conference NameMixed-Signals, Sensors, and Systems Test Workshop, 2008. IMS3TW 2008. IEEE 14th International
Pagination1 -6
Date Publishedjun.
Keywordsadhesion, adhesive properties, bioMEMS, cell culture, cellular transport, channel design, electrokinetic cell handling, flowrate control, gels, hydrogels, incubation, integrated microfluidic systems, lab-on-a-chip, lab-on-a-chip system, microchannel flow, nutrient transport, temperature control, waste transport

The integration of cell culture and characterization onto a miniaturized platform promises to benefit many applications such as tissue engineering, drug screening, and those involving small, precious cell populations. Microfluidic technology provides the tools for creating more in vivo like environments for cell culture, and the integration of electrodes into the lab-on-a-chip system permit temperature control, electrokinetic cell handling, and dielectric characterization. We use hydrogels to trap and release cells for incubation. The porous nature of these gels allows the transport of nutrient and waste, and the gel network can also present specific adhesive properties for attachment of cells. Channel design and flowrate control are crucial in determining hydrogel geometry, while on-chip temperature control triggers reversible gel formation.


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