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| Title | MEMS-based sonoporation devices for intratumoral gene therapy |
| Publication Type | Conference Paper |
| Year of Publication | 2005 |
| Authors | Siu, T., D. M. Trivedi, M. Chiao, and R. Rohling |
| Conference Name | Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Paper s. Transducers '05. The 13th International Conference on |
| Pagination | 205 - 208 Vol. 1 |
| Date Published | jun. |
| Keywords | 0.75 mm, 1 cm, biomedical equipment, biomedical ultrasonics, cavitation, cavitation-induced sonoporation, cell transfection, cellular biophysics, genetics, human prostate cancer cells, human umbilical vein endothelial cells, HUVEC, intratumoral gene therapy, MEMS-based sonoporation devices, micromechanical devices, oligonucleotides, patient treatment, PC3, PZT plate |
| Abstract | This paper presents a miniature device for intratumoral delivery of oligonucleotides (ASO). A PZT plate (1 cm2 times; 0.75mm) is used to transfect cells using cavitation-induced sonoporation. Both human umbilical vein endothelial cells (HUVEC) and human prostate cancer cells (PC3) are investigated in vitro. Preliminary results show that after cavitation-induced sonoporation, the transfection rate for HUVEC increases by 10% compared to controls (p<0.01). For PC3, the transfection rate increases by 7% compared to controls (p<0.01). |
| URL | http://dx.doi.org/10.1109/SENSOR.2005.1496394 |
| DOI | 10.1109/SENSOR.2005.1496394 |