MEMS-based sonoporation devices for intratumoral gene therapy

TitleMEMS-based sonoporation devices for intratumoral gene therapy
Publication TypeConference Paper
Year of Publication2005
AuthorsSiu, T., D. M. Trivedi, M. Chiao, and R. Rohling
Conference NameSolid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Paper s. Transducers '05. The 13th International Conference on
Pagination205 - 208 Vol. 1
Date Publishedjun.
Keywords0.75 mm, 1 cm, biomedical equipment, biomedical ultrasonics, cavitation, cavitation-induced sonoporation, cell transfection, cellular biophysics, genetics, human prostate cancer cells, human umbilical vein endothelial cells, HUVEC, intratumoral gene therapy, MEMS-based sonoporation devices, micromechanical devices, oligonucleotides, patient treatment, PC3, PZT plate

This paper presents a miniature device for intratumoral delivery of oligonucleotides (ASO). A PZT plate (1 cm2 times; 0.75mm) is used to transfect cells using cavitation-induced sonoporation. Both human umbilical vein endothelial cells (HUVEC) and human prostate cancer cells (PC3) are investigated in vitro. Preliminary results show that after cavitation-induced sonoporation, the transfection rate for HUVEC increases by 10% compared to controls (p<0.01). For PC3, the transfection rate increases by 7% compared to controls (p<0.01).


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