Title | Ion channels - estimation and control at macroscopic and nano scales |
Publication Type | Conference Paper |
Year of Publication | 2004 |
Authors | Krishnamurthy, V. |
Conference Name | Control Conference, 2004. 5th Asian |
Pagination | 42 - 50 Vol.1 |
Date Published | jul. |
Keywords | biocontrol, bioelectric phenomena, biology, biomembrane transport, electrical activities, gating problem, hidden Markov model signal processing, hidden Markov models, ion channel control, ion channel estimation, macroscopic scale, membrane ion channel, molecular level, nanoscale, nervous system, optimisation, permeation problem, physiological models, stochastic control, stochastic optimization, stochastic processes, stochastic systems |
Abstract | All electrical activities in the nervous system, including communications between cells and the influence of hormones and drugs on cell function, are regulated by membrane ion channels. Therefore understanding their mechanisms at a molecular level is a fundamental problem in biology. This paper shows how ideas in hidden Markov model signal processing, stochastic control and stochastic optimization can be used to understand the operation of ion channels at both a macroscopic and nano scales. |
URL | http://dx.doi.org/10.1109/ASCC.2004.184743 |
DOI | 10.1109/ASCC.2004.184743 |