Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy

TitleMiniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy
Publication TypeJournal Article
Year of Publication2008
AuthorsJung, W., S. Tang, D. T. McCormic, T. Xie, Y. - C. Ahn, J. Su, I. V. Tomov, T. B. Krasieva, B. J. Tromberg, and Z. Chen
JournalOptics Letters
Volume33
Pagination1324-6
Date PublishedJun
Abstract

A factor that limits the use of multiphoton microscopy (MPM) in clinical and preclinical studies is the lack of a compact and flexible probe. We report on a miniaturized MPM probe employing a microelectromechanical system (MEMS) scanning mirror and a double-clad photonic crystal fiber (DCPCF). The use of a MEMS mirror and a DCPCF provides many advantages, such as size reduction, rapid and precise scanning, efficient delivery of short pulses, and high collection efficiency of fluorescent signals. The completed probe was 1 cm in outer diameter and 14 cm in length. The developed probe was integrated into an MPM system and used to image fluorescent beads, paper, and biological specimens.

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