Introduction to automated drug delivery in clinical anesthesia

TitleIntroduction to automated drug delivery in clinical anesthesia
Publication TypeJournal Article
Year of Publication2005
AuthorsBibian, S., C. R. Ries, M. Huzmezan, and G. Dumont
JournalEuropean Journal of Control
Volume11
Pagination535–557
ISSN0947-3580
Abstract

Control technology has been applied to a wide variety of industrial and domestic applications to improve performance, safety and efficiency. Anesthesia, a critical aspect of clinical and emergency medicine, has not yet benefited from such technological advances. The lack of dedicated feedback sensors, and the large inter- and intra-patient variability in terms of patients' response to drug administration, have seriously limited the effectiveness and reliability of closed-loop controllers in clinical settings. However, recent advances in sensing devices, along with robust nonlinear control theories, have generated new hopes that the gap between manual and automated control of anesthesia can finally be bridged. This paper addresses the pharmacological principles of clinical anesthesia in a context appropriate for control engineers. Concepts and terminology, monitoring issues, as well as drug close vs. response relationships, are covered.

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