Customised cytoarchitectonic probability maps using deformable registration: primary auditory cortex

TitleCustomised cytoarchitectonic probability maps using deformable registration: primary auditory cortex
Publication TypeJournal Article
Year of Publication2007
AuthorsBailey, L., P. Abolmaesumi, J. Tam, P. Morosan, R. Cusack, K. Amunts, and I. Johnsrude
JournalMed Image Comput Comput Assist Interv
Volume10
Pagination760-8
Abstract

A novel method is presented for creating a probability map from histologically defined cytoarchitectonic data, customised for the anatomy of individual fMRI volunteers. Postmortem structural and cytoarchitectonic information from a published dataset is combined with high resolution structural MR images using deformable registration of a region of interest. In this paper, we have targeted the three sub-areas of the primary auditory cortex (located on Heschl's gyrus); however, the method could be applied to any other cytoarchitectonic region. The resulting probability maps show a significantly higher overlap than previously generated maps using the same cytoarchitectonic data, and more accurately span the macroanatomical structure of the auditory cortex. This improvement indicates a high potential for spatially accurate fMRI analysis, allowing more reliable correlation between anatomical structure and function. We validate the approach using fMRI data from nine individuals, taken from a published dataset. We compare activation for stimuli evoking a pitch percept to activation for acoustically matched noise, and demonstrate that the primary auditory cortex (Te1.0) and the lateral region Te1.2 are sensitive to pitch, whereas Te1.1 is not.

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